反应详情

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(2-difluoromethyl-6-oxo-8-phenyl-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (29 mg, 58%). 1H NMR (400 MHz, DMSO-d6): δ 7.78 (d, J=8.7 Hz, 1H), 7.59 (d, J=8.7 Hz, 1H), 7.50-7.46 (m, 2H), 7.45-7.34 (m, 5H), 7.27-7.23 (m, 2H), 7.12 (t, J=53.8 Hz, 1H), 2.55-2.46 (m, 2H), 2.34-2.25 (m, 2H), 2.13-2.03 (m, 1H), 1.80-1.70 (m, 1H). LCMS (Method E): RT=3.14 min, [M+H]+=458.

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