HRID1037417
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Following the procedure used to prepare 3-(4-(1-aminocyclobutyl)phenyl)-2-phenyl-8-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4H-pyrano[2,3-c]pyridin-4-one, tert-butyl 1-(4-(8-(1,5-dimethyl-1H-pyrazol-4-yl)-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)phenyl)cyclobutylcarbamate was reacted to give the title compound (15 mg, 46%) as an HCl salt. 1H NMR (500 MHz, CD3OD): δ 8.78 (d, J=8.2 Hz, 1H), 8.25 (bs, 1H) 8.15 (d, J=8.3 Hz, 1H), 7.60-7.35 (m, 11H), 3.91 (s, 3H), 2.80-2.78 (m, 2H), 2.65-2.60 (m, 2H), 2.55 (s, 3H), 2.29-2.20 (m, 1H), 2.01-1.91 (m, 1H). LCMS (Method I): RT=4.82 min, [M+F1]+=463.
WORKUP
后处理
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