反应详情

Compound (47) was prepared by the following method: To a suspension of 6-amino-2-(4-bromophenyl)-5-cyclopropyl-N-methyl-2H-indazole-3-carboxamide (20 mg, 0.052 mmol) in neat pyridine (1 mL) at 0° C. was added difluoromethanesulfonyl chloride (60 μL). After 3 d, the reaction was quenched with saturated aqueous ammonium chloride (1 mL) and then extracted with ethyl acetate (3×2 mL). The combined organics were washed with 1M aqueous citric acid (2 mL), brine (2 mL) then dried (MgSO4) and concentrated to dryness to afford crude 2-(4-Bromophenyl)-5-cyclopropyl-6-{[(difluoromethyl)sulfonyl]amino}-N-methyl-2H-indazole-3-carboxamide (18 mg, 69%) which was used without further purification.

1. customCompound (47) was prepared by the following method
2. customthe reaction was quenched with saturated aqueous ammonium chloride (1 mL)
3. extractionextracted with ethyl acetate (3×2 mL)
4. washThe combined organics were washed with 1M aqueous citric acid (2 mL), brine (2 mL)
5. dry with materialthen dried (MgSO4)
6. concentrationconcentrated to dryness