反应详情

(Z)-1-[2-(benzyloxy)ethyl]-4-{4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl]-2-(prop-1-en-1-yl)phenyl}piperazine (33 mg, 0.0604 mmol) was dissolved in methanol (4 mL), added palladium carbon (3.3 mg), and the mixture was stirred at room temperature for 12 hours under a hydrogen atmosphere. The reaction solution was filtered through a pad of celite, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/acetone). The title compound (7.8 mg (yield 24%)) was obtained as a yellow oil.

1. filtrationThe reaction solution was filtered through a pad of celite
2. concentrationconcentrated in vacuo
3. customThe obtained residue was purified by silica-gel column chromatography (hexane/acetone)