反应详情

3-[2-(4-{6-[2-(Benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-4-propylpyridin-3-yl}piperazin-1-yl)-2-oxoethyl]-5-(2,3-dihydrobenzofuran-5-yl)-5-methylimidazolidine-2,4-dione (13 mg, 0.0170 mmol) was dissolved in methanol (1.5 mL), added palladium carbon (2.0 mg), and the mixture was stirred at room temperature for 2 hours under a hydrogen atomosphere. The reaction solution was filtered through a pad of celite, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/acetone), and the title compound (7.3 mg (yield 80%)) was obtained as a yellow oil.

1. filtrationThe reaction solution was filtered through a pad of celite
2. concentrationconcentrated in vacuo
3. customThe obtained residue was purified by silica-gel column chromatography (hexane/acetone)