反应详情

A mixture of 7-ethyl-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxamide (3.4 g), a Lawesson's reagent (2.3 g), and dry tetrahydrofuran (70 mL) was stirred at 55° C. for 3 hr. The reaction solution was concentrated under reduced pressure, and the obtained residue was subjected to silica gel column chromatography (ethyl acetate:hexane=25:75 to 60:40, volume ratio), and the obtained yellow crystals were washed with ethyl acetate-hexane to give the title compound (2.8 g, yield 79%) as pale-yellow crystals.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. washthe obtained yellow crystals were washed with ethyl acetate-hexane