反应详情

A solution of methyl 9-{(2R,3R,4R,5S)-3,4-bis(benzoyloxy)-5-[(ethylamino)carbonyl]-tetrahydro-2-furanyl}-6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate (Preparation 8) (3.4 g, 4.5 mmol) and sodium carbonate (50 mg) in dry methanol (60 ml) was stirred at room temperature for four hours. Solvent was removed under reduced pressure and the residue taken up in a mixture of dichloromethane:methanol (95:5, by volume, 60 ml). Inorganic salts were filtered off and the filtrate evaporated under reduced pressure. The residue was triturated with diethyl ether, filtered off and dried to yield the title compound as a white solid, (2.4 g, 98%).

1. customSolvent was removed under reduced pressure
2. additionthe residue taken up in a mixture of dichloromethane:methanol (95:5, by volume, 60 ml)
3. filtrationInorganic salts were filtered off
4. customthe filtrate evaporated under reduced pressure
5. customThe residue was triturated with diethyl ether
6. filtrationfiltered off
7. customdried