反应详情

2-amino-4-fluoro-N-methoxybenzamide (90 mg, 0.49 mmol) and N-(1,3-dimethylpyrazol-4-yl)-4-iodo-5-(trifluoromethyl)pyridin-2-amine (110 mg, 0.29 mmol) were reacted according to the procedure of example 14.01. After chromatography, the solvent was evaporated to dryness, the residue triturated in tBuOMe and the resulting precipitate was collected by filtration and dried to a constant weight to afford the title compound (50 mg, 39.6%) as a white solid. NMR Spectrum: (DMSO-d6) 2.08 (s, 3H), 3.70 (s, 3H), 3.71 (s, 3H), 6.71 (bs, 1H), 6.93 (ddd, 1H), 7.36 (dd, 1H), 7.66 (dd, 1H), 7.87 (s, 1H), 8.24 (1, 1H), 8.52 (s, 1H), 9.99 (bs, 1H), 11.95 (s, 1H); Mass spectrum: MH+ 439

1. customAfter chromatography, the solvent was evaporated to dryness
2. customthe residue triturated in tBuOMe
3. filtrationthe resulting precipitate was collected by filtration
4. customdried to a constant weight