反应详情

tert-Butyl (1-{4-[2-(4-acetylphenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate (27 mg, 0.045 mmol) in MeOH (0.5 mL) was added 4N HCl-dioxane (2 mL) and stirred at room temperature for 22.5 hours. The mixture was concentrated to afford the desired product (27 mg, 98%) as a pale yellow solid. 1HNMR (DMSO-d6) 400 MHz δ: 8.66-8.63 (m, 3H), 8.11 (dd, J=4.6 Hz and 1.7 Hz, 1H), 7.98 (dd, J=8.0 Hz and 1.7 Hz, 1H), 7.88 (d, J=8.6 Hz, 2H), 7.61 (d, J=8.6 Hz, 2H), 7.56 (d, J=8.6 Hz, 2H), 7.35-7.35 (m, 2H), 7.31 (d, J=7.4 Hz, 1H), 7.14 (t, J=7.2 Hz, 1H), 6.91 (dd, J=8.0 Hz and 1.7 Hz, 1H), 6.74 (dd, J=8.0 Hz and 4.6 Hz, 1H), 3.73-3.70 (m, 1H), 3.68-3.65 (m, 1H), 2.64-2.53 (m, 5H), 2.24-2.15 (m, 1H), 1.89-1.80 (m, 1H). LCMS: 498 [M+H].

1. concentrationThe mixture was concentrated