反应详情

10% Pd/C (51.4 mg) was added to a solution of tert-butyl (1-{4-[2-(4-nitrophenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate (51.4 mg, 0.0856 mmol) in MeOH (5 mL), and the mixture was stirred for 4 hours under hydrogen atmosphere. The catalyst was filtered off and washed with MeOH. The combined filtrate and washings were concentrated, and the residue was purified by PTLC (CHCl3/MeOH=9:1) to afford desired product (32.0 mg, 65.5%) as an orange solid. 1HNMR (CDCl3) 400 MHz δ: 8.16 (dd, J=7.8, 1.4 Hz, 1H), 8.02-7.97 (m, 1H), 7.46-7.24 (m, 5H), 7.18-7.09 (m, 3H), 6.97-6.91 (m, 1H), 6.83-6.73 (m, 1H), 6.64-6.55 (m, 3H), 6.45 (s, 1H), 5.21 (br s, 1H), 3.70 (br s, 2H), 2.65-2.25 (m, 4H), 2.19-2.05 (m, 1H), 1.94-1.81 (m, 1H), 1.38 (br s, 9H).

1. filtrationThe catalyst was filtered off
2. washwashed with MeOH
3. concentrationThe combined filtrate and washings were concentrated
4. customthe residue was purified by PTLC (CHCl3/MeOH=9:1)