反应详情

To a solution of methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetate (34 mg, 0.067 mmol; Example 153, Step B) in THF/MeOH/H2O (1/1/1, 0.48 mL) was added 2 M lithium hydroxide (67 uL, 0.134 mmol) at rt. After being stirred at rt for 4 h, the reaction was quenched saturated aqueous NH4Cl and extracted (2×DCM) and the combined organic layers were washed (1×sat. aq. NaCl solution) and concentrated under the reduced pressure. Purification of the residue by flash chromatography on silica gel (eluent: 70 to 100% EtOAc/hexanes) provided the title compound.

1. customthe reaction was quenched saturated aqueous NH4Cl
2. extractionextracted (2×DCM)
3. washthe combined organic layers were washed (1×sat. aq. NaCl solution)
4. concentrationconcentrated under the reduced pressure
5. customPurification of the residue by flash chromatography on silica gel (eluent: 70 to 100% EtOAc/hexanes)