反应详情

温度

100 °C

To a solution of 5-((3-(((tert-butyldiphenylsilyl)oxy)methyl)phenyl) (cyclopropyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (5.07 g) in DMF (40 mL) was added ethanol (20 mL), and the mixture was stirred at 100° C. for 4 hr. The reaction mixture was concentrated under reduced pressure, and water was added to the residue. The mixture was extracted with ethyl acetate, and the extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (4.55 g) as a pale-yellow oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure, and water
2. additionwas added to the residue
3. extractionThe mixture was extracted with ethyl acetate
4. washthe extract was washed with saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was evaporated under reduced pressure
7. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)