反应详情

To a solution of tert-butyl 2′-fluoro-5′-methoxy-2-(3-methyl-3-((trimethylsilyl)oxy)but-1-yn-1-yl)biphenyl-4-yl carbonate (480 mg) in THF (3 mL) was added a solution (1 M, 2.0 mL) of tetrabutylammonium fluoride in THF, and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with ethyl acetate. The diluted solution was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (343 mg) as a colorless oil.

1. washThe diluted solution was washed with water and saturated brine
2. dry with materialdried over anhydrous sodium sulfate
3. customThe solvent was evaporated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)