反应详情

温度

40 °C

Compound 5-chloro-N-(((3S,3aS)-1-oxo-7-(2-t-butylaminosulfonylphenyl)-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl)methyl)thiophene-2-carboxamide (124 mg, 0.215 mmol) was dissolved in 2 ml of TFA. The resulting mixture was heated to 40° C. and agitated for 2 h. TLC (PE/EA=1/1) was employed to monitor the reaction. After the reaction completed, TFA was evaporated, and the remainder was diluted by 20 ml of EA, washed with 8 ml of water and 8 ml of saturated saline solution for one time each, dried over anhydrous sodium sulfate, and the solvent was evaporated. Column chromatography (PE/EA=2/1) afforded 91 mg of white solid, yield: 81.22%.

1. customthe reaction
2. customTFA was evaporated
3. additionthe remainder was diluted by 20 ml of EA
4. washwashed with 8 ml of water and 8 ml of saturated saline solution for one time each,
5. dry with materialdried over anhydrous sodium sulfate
6. customthe solvent was evaporated