反应详情

3-(Tetrahydro-pyran-4-ylamino)-isoquinoline-6-carboxylic acid [(R)-1-(4-chloro-3-fluoro-phenyl)-propyl]-amide (II-2) was prepared analogously except in step 2 (S)-2-aminopropan-1-ol was replaced with 4-amino-tetrahydropyran and in step 5, 50c was replaced with (R)-1-(4-chloro-3-fluoro-phenyl)propan-1-amine hydrochloride (70b). 1H NMR (400 MHz, DMSO-d6) δ 8.91 (s, 1H), 8.87 (d, J=8.2 Hz, 1H), 8.05 (s, 1H), 7.85 (d, J=8.5 Hz, 1H), 7.55 (t, J=8.1 Hz, 1H), 7.51 (d, J=8.5 Hz, 1H), 7.46 (dd, J=10.6, 1.5 Hz, 1H), 7.29 (d, J=8.3 Hz, 1H), 6.74 (s, 1H), 6.51 (d, J=7.9 Hz, 1H), 4.95 (dd, J=14.8, 8.3 Hz, 1H), 3.90 (m, 2H), 3.83 (m, 1H), 3.45 (t, J=10.7 Hz, 2H), 1.92 (m, 2H), 1.89-1.73 (m, 2H), 1.56-1.43 (m, 2H), 0.92 (t, J=7.3 Hz, 3H).