反应详情

3-((3S,4S)-3-Fluoro-tetrahydro-pyran-4-ylamino)-isoquinoline-6-carboxylic acid [(S)-2-hydroxy-1-(4-methoxy-phenyl)-ethyl]-amide (II-43) was prepared analogously except in step 2, (S)-2-aminopropan-1-ol was replaced with (3S,4S)-3-fluorotetrahydro-2H-pyran-4-amine (71c) and in step 5, 50c was replaced with (S)-2-amino-2-(4-methoxyphenyl)ethanol hydrochloride (62c). 1H NMR (500 MHz, DMSO-d6): δ 8.93 (s, 1H), 8.80 (d, J=8.5 Hz, 1H), 8.09 (s, 1H), 7.87 (d, J=9.0 Hz, 1H), 7.56 (d, J=9.0 Hz, 1H), 7.33 (d, J=8.5 Hz, 2H), 6.90 (s, 1H), 6.89 (d, J=8.5 Hz, 2H), 6.67 (d, J=8.5 Hz, 1H), 5.07-5.02 (m, 1H), 4.92 (t, J=11.5 Hz, 1H), 4.78 (d, J=50.0 Hz, 1H), 4.30-4.20 (m, 1H), 4.05-3.99 (m, 1H), 3.94-3.90 (m, 1H), 3.73-3.50 (m, 7H), 1.92-1.80 (m, 1H), 1.75-1.70 (m, 1H).