反应详情

温度

50 °C

A solution of (S)-1-(5-(methoxymethoxy)-2-methyl-3,4-dihydroquinolin-1(2H)-yl)ethanone (1.6 g, 6.42 mmol) in methanol (16 mL) was treated with concentrated hydrochloric acid (1.0 mL, 12.8 mmol) at rt. The solution was heated to 50° C. for 90 min. Heating was discontinued, and the solution was allowed to slowly cool to room temperature overnight. Methanol was removed under reduced pressure and the residue was partitioned between dichloromethane and water. The aqueous layer was separated and extracted with dichloromethane. The combined organic extracts were concentrated under reduced pressure. The residue was dissolved in acetonitrile (ca. 20-30 mL), and then concentrated under reduced pressure to afford (S)-1-(5-hydroxy-2-methyl-3,4-dihydroquinolin-1(2H)-yl)ethanone (1.23 g, 93%) as an off-white to tan solid. MS (ESI, pos. ion) m/z 206 [M+1]+.

1. temperatureHeating
2. temperatureto slowly cool to room temperature overnight
3. customMethanol was removed under reduced pressure
4. customthe residue was partitioned between dichloromethane and water
5. customThe aqueous layer was separated
6. extractionextracted with dichloromethane
7. concentrationThe combined organic extracts were concentrated under reduced pressure
8. dissolutionThe residue was dissolved in acetonitrile (ca. 20-30 mL)
9. concentrationconcentrated under reduced pressure