反应详情

(S)-tert-Butyl (1-(5-(6-(4-isopropylpiperazin-1-yl)-6-oxohex-1-yn-1-yl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (134 mg, 0.23 mmol) was dissolved in hydrogen chloride (4M in dioxane, 2.5 ml, 10 mmol) and stirred at room temperature overnight. The solvent was removed and tert-butanol and DIEA were added to the crude and the reaction mixture was stirred at 120° C. overnight. The solvents were removed and this crude was used in the following step without further purification. Purity 10%

1. customThe solvent was removed
2. additiontert-butanol and DIEA were added to the crude
3. stirringthe reaction mixture was stirred at 120° C. overnight
4. customThe solvents were removed
5. customthis crude was used in the following step without further purification