反应详情

温度

45 °C

(S)-2-(1-((5-(3-Amino-5-methoxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (50 mg, 0.08 mmol) was treated with pyridine (22 μl, 0.27 mmol), methanesulfonyl chloride (18 μl, 0.23 mmol) and 0.75 ml tetrahydrofuran as a solvent according to the method described in Preparation 175 but heating at 45° C. during 48 h. The residue was purified using SP1® Purification System (0% to 70% hexane-ethyl acetate) to obtain 42 mg (67% yield, 89% purity) of the title compound.

1. customdescribed in Preparation 175
2. customThe residue was purified
3. customSP1® Purification System (0% to 70% hexane-ethyl acetate)