HRID1052595

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31297

Methanesulfonyl chloride

CH3ClO2S

结构：Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Sc3cccc(N)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12

HCID131736218

未命名化合物

PRODUCTS

生成物

结构：Cc1ccn2nc([C@H](C)Nc3ncnc4c3c(Sc3cccc(NS(C)(=O)=O)c3)cn4COCC[Si](C)(C)C)n(-c3ccccc3)c(=O)c12

HCID131736219

未命名化合物

收率 23%

PROCEDURE

实验过程

(S)-2-(1-((5-((3-Aminophenyl)thio)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (100 mg, 0.13 mmol) was treated with methanesulfonyl chloride (10 μl, 0.14 mmol) according to the method described in Preparation 15b. The residue was purified by reverse phase using SP1® Purification System to give 20 mg (23% yield) of the title compound. Purity 98%.

WORKUP

后处理

customThe residue was purified by reverse phase
custom® Purification System

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-65394a9452474d3ab5ce60fea9fd8fad
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09388189B2
来源说明: uspto-grants-2016_07

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([S:8][C:9]2[C:17]3[C:16]([NH:18][C@H:19]([C:21]4[N:26]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)[C:25](=[O:33])[C:24]5=[C:34]([CH3:37])[CH:35]=[CH:36][N:23]5[N:22]=4)[CH3:20])=[N:15][CH:14]=[N:13][C:12]=3[N:11]([CH2:38][O:39][CH2:40][CH2:41][Si:42]([CH3:45])([CH3:44])[CH3:43])[CH:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:46][S:47](Cl)(=[O:49])=[O:48]>>[CH3:37][C:34]1[CH:35]=[CH:36][N:23]2[C:24]=1[C:25](=[O:33])[N:26]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]([C@@H:19]([NH:18][C:16]1[C:17]3[C:9]([S:8][C:4]4[CH:3]=[C:2]([NH:1][S:47]([CH3:46])(=[O:49])=[O:48])[CH:7]=[CH:6][CH:5]=4)=[CH:10][N:11]([CH2:38][O:39][CH2:40][CH2:41][Si:42]([CH3:43])([CH3:45])[CH3:44])[C:12]=3[N:13]=[CH:14][N:15]=1)[CH3:20])=[N:22]2