反应详情

(S)—N-Methyl-3-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzenesulfonamide (76 mg, 0.08 mmol) was treated with trifluoroacetic acid (1.52 ml, 18.73 mmol) and a solution of ammonia (7N in methanol, 1.52 ml, 10.64 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 15% dichloromethane-2-propanol) to obtain 34 mg (71% yield) of the title compound.

1. customThe residue was purified
2. customSP1® Purification System (0% to 15% dichloromethane-2-propanol)