反应详情

A solution containing the crude 53 (3.0 g, 4.6 mmol) in THF (20 mL) was treated with 3 M NaOH (8 mL) at ambient temperature. The reaction mixture was then warmed to gentle reflux and maintained for 2.5 h. The reaction mixture was concentrated in vacuo and the residue was dissolved in EtOAc. The organic solution was washed with 1 N HCl then dried over anhydrous Na2SO4, filtered and concentrated to afford ˜3 g (quant.) of 54 as an off-white-colored foam which was used directly without further purification. 1H NMR (CDCl3, 300 MHz) δ7.69-7.67 (m, 1H), 7.39-7.20 (m, 8H), 5.70 (d, J=8.4 Hz, 1H), 5.13-5.09 (m, 2H), 4.50-4.45 (m, 1H), 3.67-3.54 (m, 1H), 3.22-3.18 (m, 2H), 3.13 (t, J=6.9 Hz, 1H), 2.85-2.78 (m, 2H), 2.09-1.97 (m, 3H), 1.76-1.62 (m, 4H), 1.43 (s, 9H) ppm.

1. temperatureThe reaction mixture was then warmed
2. temperatureto gentle reflux
3. temperaturemaintained for 2.5 h
4. concentrationThe reaction mixture was concentrated in vacuo
5. dissolutionthe residue was dissolved in EtOAc
6. washThe organic solution was washed with 1 N HCl
7. dry with materialthen dried over anhydrous Na2SO4
8. filtrationfiltered
9. concentrationconcentrated