(Pyridin-4-yl)boronic acid → 2-Phenyl-5-(pyridin-4-ylmethyl)pyridine

HRID 1054104Notes

Reaction equation

HRID 1054104 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:7][CH:8]=1.[N:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[C:9]1([C:6]2[CH:5]=[CH:4][C:3]([CH2:2][C:18]3[CH:19]=[CH:20][N:15]=[CH:16][CH:17]=3)=[CH:8][N:7]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 159459965-(Bromomethyl)-2-phenylpyridine

Product 1

HCID 573300092-Phenyl-5-(pyridin-4-ylmethyl)pyridine

Procedure

Synthesized using compound 61a (355 mg, 1.43 mmol) and 4-pyridineboronic acid (264 mg, 2.15 mmol) according to Method C. Crude product was purified by flash chromatography on silica-gel using a mixture of hexane/ethyl acetate (2:1) as eluent. After flash chromatography the product was solved in ethyl acetate and a few drops of conc. HCl and water were added. After stirring for 30 minutes the phases were separated and water phase was neutralized with aqueous Na2CO3-solution (2M). After extraction with ethyl acetate and drying over MgSO4 the solvent was removed under vacuum. Beige solid. Yield: 140 mg, 40%. 1H NMR (CDCl3, 500 MHz): δH (ppm)=3.77 (s, 2H), 6.88-6.93 (m, 2H), 7.15-7.21 (m, 1H), 7.21-7.31 (m, 3H), 7.45 (dd, J=8.2, 0.9 Hz, 1H), 7.72-7.78 (m, 2H), 8.28-8.33 (m, 2H), 8.33-8.37 (m, 1H); 13C NMR (CDCl3, 125 MHz): δC (ppm)=38.0, 120.3, 124.0, 126.7, 128.7, 128.9, 132.7, 137.1, 138.9, 148.7, 149.9, 150.0, 156.0; (ESI): m/z=246.85 [M+H]+.

Workup

  1. customSynthesized
  2. customCrude product was purified by flash chromatography on silica-gel
  3. additiona mixture of hexane/ethyl acetate (2:1) as eluent
  4. additiona few drops of conc. HCl and water were added
  5. customwere separated
  6. extractionAfter extraction with ethyl acetate
  7. dry with materialdrying over MgSO4 the solvent
  8. customwas removed under vacuum

Sources & evidence

ORD record
ord-546d82bfee4b49a98007fa1b70d8fd7c
Source dataset
uspto-grants-2016_07
Patent number
US09394290B2

Reaction notes

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