反应详情

At 0° C., 1 g (10.7 mmol) of 1H-pyrazole-4-carbonitrile and 2.4 g (11.8 mmol) of 4-methoxybenzyl bromide were initially charged in 22 ml of THF. 1.3 g (11.8 mmol) of potassium tert-butoxide were added a little at a time, and the reaction was stirred at RT overnight. The precipitated solid was then filtered off, and the mother liquor was freed from the solvent on a rotary evaporator. The residue was dissolved in ethyl acetate and the solution was washed with water and saturated sodium chloride solution, dried over sodium sulphate, filtered and concentrated. This gave 2 g (87% of theory) of the title compound, which was used without further purification for the subsequent step.

1. filtrationThe precipitated solid was then filtered off
2. customthe mother liquor was freed from the solvent on a rotary evaporator
3. dissolutionThe residue was dissolved in ethyl acetate
4. washthe solution was washed with water and saturated sodium chloride solution
5. dry with materialdried over sodium sulphate
6. filtrationfiltered
7. concentrationconcentrated
8. customThis gave 2 g (87% of theory) of the title compound, which was used without further purification for the subsequent step