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With gentle heating, 125 g (812 mmol, purity 95%) of 3-oxo-3-(pyridin-3-yl)propionitrile [lit. for example: P. Seneci et al., Synth. Commun. 1999, 29 (2), 311-341; also available commercially] were dissolved in 1.25 liters of ethanol. 126 g (853 mmol) of (2,2-diethoxyethyl)hydrazine and 4.1 ml (4.06 mmol) of 1 M hydrochloric acid were then added. The reaction mixture was heated under reflux for 4 h, and all volatile components were then substantially removed on a rotary evaporator. The residue obtained was taken up in ethyl acetate, and the solution was washed with water and dried over anhydrous magnesium sulphate. After filtration, the mixture was evaporated to dryness. The residue that remained was triturated with diisopropyl ether at RT. The resulting solid was then filtered off with suction and dried under high vacuum. This gave 153 g (65% of theory, purity 96%) of the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 4 h
3. customall volatile components were then substantially removed on a rotary evaporator
4. customThe residue obtained
5. washthe solution was washed with water
6. dry with materialdried over anhydrous magnesium sulphate
7. filtrationAfter filtration
8. customthe mixture was evaporated to dryness
9. customThe residue that remained was triturated with diisopropyl ether at RT
10. filtrationThe resulting solid was then filtered off with suction
11. customdried under high vacuum