反应详情

Analogously to Example 13A/Step 1, 2.22 g (8.01 mmol) of the compound of Example 78A and 1.90 g (8.81 mmol) of 2-bromo-4-nitrotoluene gave, after 3 h of heating under reflux, a crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol). This gave 1.93 g (49% of theory) of the title compound.

1. customgave, after 3 h
2. temperatureof heating
3. temperatureunder reflux
4. customa crude product which was purified by chromatography on a Biotage system (100 g Snap column; mobile phase gradient ethyl acetate/0-8% methanol)