反应详情

温度

80 °C

68 mg (76% pure, 79 μmol) of the compound of Example 57A were initially charged in 0.32 ml of trifluoroacetic acid and stirred at 80° C. for 3 h. The mixture was then purified directly by preparative HPLC (Method 29). The product fractions were concentrated under reduced pressure and the residue was taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried over sodium sulphate, filtered and concentrated under reduced pressure. This gave 41 mg (97% of theory) of the title compound.

1. customThe mixture was then purified directly by preparative HPLC (Method 29)
2. concentrationThe product fractions were concentrated under reduced pressure
3. washwashed with saturated aqueous sodium bicarbonate solution
4. dry with materialThe organic phase was dried over sodium sulphate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure