HRID1055727

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1cc(C(=O)O)cc(S(F)(F)(F)(F)F)c1

HCID86690975

未命名化合物

HCID89700023

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2cc(C(C)(C)O)cc(S(F)(F)(F)(F)F)c2)cc1-n1ccn2nc(-c3cccnc3)cc12

HCID89700057

未命名化合物

PROCEDURE

实验过程

50 mg (0.17 mmol) of the compound of Example 6A and 52.9 mg (0.17 mmol) of the compound of Example 19A were reacted and worked up analogously to the procedure of Example 19. This gave 49 mg (49% of theory) of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ed262cfa6f6d48b59be467cafeb8bbf3
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394309B2
来源说明: uspto-grants-2016_07

反应 SMILES

[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[OH:23][C:24]([C:27]1[CH:28]=[C:29]([CH:33]=[C:34]([S:36]([F:41])([F:40])([F:39])([F:38])[F:37])[CH:35]=1)[C:30](O)=[O:31])([CH3:26])[CH3:25]>>[OH:23][C:24]([C:27]1[CH:28]=[C:29]([CH:33]=[C:34]([S:36]([F:41])([F:37])([F:38])([F:39])[F:40])[CH:35]=1)[C:30]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:31])([CH3:25])[CH3:26]