HCID 86690975, compound → 3-(2-Hydroxypropan-2-yl)-N-{4-methyl-3 [6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055727Notes

Reaction equation

HRID 1055727 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[OH:23][C:24]([C:27]1[CH:28]=[C:29]([CH:33]=[C:34]([S:36]([F:41])([F:40])([F:39])([F:38])[F:37])[CH:35]=1)[C:30](O)=[O:31])([CH3:26])[CH3:25]>>[OH:23][C:24]([C:27]1[CH:28]=[C:29]([CH:33]=[C:34]([S:36]([F:41])([F:37])([F:38])([F:39])[F:40])[CH:35]=1)[C:30]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:31])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 86690975HCID 86690975, compoundHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Product 1

HCID 897000573-(2-Hydroxypropan-2-yl)-N-{4-methyl-3 [6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide

Procedure

50 mg (0.17 mmol) of the compound of Example 6A and 52.9 mg (0.17 mmol) of the compound of Example 19A were reacted and worked up analogously to the procedure of Example 19. This gave 49 mg (49% of theory) of the title compound.

Sources & evidence

ORD record
ord-ed262cfa6f6d48b59be467cafeb8bbf3
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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