反应详情

To tert-butyl 9-((2-((2,3-dimethyl-2H-indazol-6-yl)amino)-5-methylpyrimidin-4-yl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (1.04 g, 2.00 mmol) was added a solution of hydrogen chloride in ethyl acetate (8 mL, 3 mol/L). The reaction was stirred at rt overnight and then concentrated in vacuo. The residue was diluted with Na2CO3 solution (sat, 100 mL), the mixture was extracted with DCM/MeOH (10/1, 150 mL×3). The organic layers were dried with Na2SO4, filtered and concentrated in vacuo to give the title compound as a yellow solid (804 mg, 95.8%).

1. concentrationconcentrated in vacuo
2. additionThe residue was diluted with Na2CO3 solution (sat, 100 mL)
3. extractionthe mixture was extracted with DCM/MeOH (10/1, 150 mL×3)
4. dry with materialThe organic layers were dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo