2-Pyridyl Trifluoromethanesulfonate → HCID 18668931, compound

HRID 1058655Notes

Reaction equation

HRID 1058655 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([S:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[C:6]([CH:9]=1)[CH:7]=[O:8].FC(F)(F)S(O[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)(=O)=O>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([S:10][C:5]2[CH:4]=[CH:3][C:2]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[CH:9][C:6]=2[CH:7]=[O:8])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 39476262-Pyridyl TrifluoromethanesulfonateHCID 18668950Benzaldehyde, 5-bromo-2-[(4-methylphenyl)thio]-

Product 1

HCID 18668931HCID 18668931, compoundYield 39.3%

Procedure

The reaction was performed in accordance with a document (Tetrahedron Lett. Vol. 36, No. 50, pp. 9085-9088, 1995) and the product was treated by using 5-bromo-2-[(4-methyphenyl)thio]-benzaldehyde (0.06 g, 0.2 mmol) and 2-pyridyl trifluoromethanesulfonate (0.03 g, 0.2 mmol). The residue was purified by thin-layer chromatography (hexane: ethyl acetate=8:1)) to obtain 2-[(4-methylphenyl)thio]-5-(2-pyridyl)benzaldehyde (0.024 g, 38.5%).

Workup

  1. addition9085-9088, 1995) and the product was treated
  2. customThe residue was purified by thin-layer chromatography (hexane: ethyl acetate=8:1))

Sources & evidence

ORD record
ord-1ef08e0243244d04a33f77c5485366f9
Source dataset
uspto-grants-2003_02
Patent number
US06518268B1

Reaction notes

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