反应详情

The title compound was prepared from 5-[4-(4-oxo-piperidine-1-yl)-benzyl]-thiazolidine-2,4-dione (which was obtained in Example 38) and N-[5-(3-amino-2-hydroxy-propoxy)-2-hydroxy-phenyl]-benzenesulfonamide (which was obtained in Example 21) according to the procedure of Example 73 as an off-white solid; mp >120° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.30-1.55 (m, 2H), 1.80-2.00 (m, 2H), 2.50-4.00 (m, 12H), 4.55 (dd, J=9.6, 4.0 Hz, 1H), 6.49 (dd, J=8.7, 2.9 Hz, 1H), 6.61 (d, J=8.7 Hz, 1H), 6.77 (d, J=2.9 Hz, 1H), 6.86 (d, J=8.7 Hz, 2H), 7.05 (d, J=8.7 Hz, 2H), 7.40-7.60 (m, 3H), 7.70-7.80 (m, 2H); MS (ES) m/z: 627.0 (MH+, 100%); HRMS Calcd. for C30H35N4O7S2 (MH+): 627.1941. Found: 627.1954.