反应详情

The title compound was prepared from 1-[4-(1H-tetrazol-5-yl)-phenyl]-piperidine-4-one (which was obtained in Example 47) and N-[5-((1R)-2-amino-1-hydroxy- ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 73 as a white solid; mp >175° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.40-1.65 (m, 2H), 1.90-2.10 (m, 2H), 2.70-3.10 (m, 5H), 2.95 (s, 3H), 3.70-3.85 (m, 2H), 4.69 (dd, J=9.3, 3.0 Hz, 1H), 6.89 (d, J=8.3 Hz, 1H), 6.97 (d, J=8.9 Hz, 2H), 7.06 (dd, J=8.3, 2.0 Hz, 1H), 7.24 (d, J=2.0 Hz, 1H), 7.80 (d, J=8.9 Hz, 2H); MS (ES) m/z: 474.1 (MH+); HRMS Calcd. for C21H28N7O4S(MH+): 474.1918. Found: 474.1912.