反应详情

The title compound was prepared from 4-(4-oxo-piperidine-1-yl)-benzoic acid (which was obtained in Example 151) and glycine ethyl ester hydrochloride according to the procedure of Example 154 as a pale yellowish solid; 1H NMR (300 MHz, DMSO-d6) δ 1.20 (t, J=7.1 Hz, 3H), 2.43 (t, J=6.1 Hz, 4H), 3.72 (t, J=6.1 Hz, 4H), 3.95 (d, J=5.8 Hz, 2H), 4.10 (q, J=7.1 Hz, 2H), 7.04 (d, J=8.9 Hz, 2H), 7.77 (d, J=8.9 Hz, 2H), 8.63 (t, J=5.8 Hz, 1H); MS (ES) m/z: 305.2 (MH+); HRMS Calcd. for C18H22N2O4 (M+): 304.1423. Found: 304.1422.