反应详情

The title compound was prepared from 4-(2,4-dioxo-thiazolidin-5-ylmethyl)benzenesulfonylchloride (J. Med. Chem. 1992, 35, 1853) and 1-(4-amino-phenyl)-piperidine-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a yellowish solid; 1H NMR (300 MHz, DMSO-d6) δ 2.37 (t, J=6.0 Hz, 4H), 3.10-3.60 (m, 2H), 3.44 (t, J=6.0 Hz, 4H), 4.95 (dd, J=12.3, 6.0 Hz, 1H), 6.80-7.00 (m, 4H), 7.27 (d, J=8.1 Hz, 2H), 7.63 (d, J=8.1 Hz, 2H), 9.77 (brs, 1H), 12.09 (brs, 1H); MS (ES) m/z: 459.9 (MH+); HRMS Calcd. for C21H21N3O5S2 M+): 459.0923. Found: 459.0930.