反应详情

The title compound was prepared from 4-methoxy-N-[4-(4-oxo-piperidine-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 218) and (1R)-2-amino-1-(3-chloro-phenyl)-ethanol hydrochloride (which was obtained in Example 1) according to the procedure of Example 255 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.55-1.75 (m, 2H), 2.05-2.15 (m, 2H), 2.50-3.10 (m, 5H), 3.50-3.70 (m, 2H), 3.79 (s, 3H), 4.90-5.05 (m, 1H), 6.10-6.20 (m, 1H), 6.79 (d, J=9.0 Hz, 2H), 6.89 (d, J=9.0 Hz, 2H), 7.05 (d, J=11.8 Hz, 2H), 7.25-7.50 (m, 5H), 7.60 (d, J=11.8 Hz, 2H), 9.70 (brs, 1H); MS (ES) m/z: 482.2 (MH+); HRMS Calcd. for C26H32N3O4S(MH+): 482.2114. Found: 482.2120.