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HRID1061376

反应详情

EQUATION

反应方程式

HRID 1061376 的结构方程式

REACTANTS

反应物

2
结构：CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(N3CCC(=O)CC3)cc2)cc1
HCID22220314

未命名化合物

结构：CS(=O)(=O)Nc1cc([C@@H](O)CN)ccc1OCc1ccccc1
HCID69654885

N-[5-[(1R)-2-Amino-1-hydroxyethyl]-2-(phenylmethoxy)phenyl]methanesulfonamide

C16H20N2O4S

PRODUCTS

生成物

1
结构：CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(N3CCC(NC[C@H](O)c4ccc(O)c(NS(C)(=O)=O)c4)CC3)cc2)cc1
HCID69654783

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidine-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 225) and N-[2-benzyloxy-5-(2-amino-(1R)-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (which was obtained in Example 8) according to the procedure of Example 255 as a grey solid; 1H NMR (300 MHz, DMSO-d6) δ 0.86 (t, J=6.9 Hz, 3H), 1.20-1.80 (m, 10H), 1.95-2.15 (m, 2H), 2.50-3.30 (m, 7H), 2.97 (s, 3H), 3.55-3.70 (m, 2H), 4.70-4.85 (m, 1H), 5.90-6.10 (m, 1H), 6.48 (t, J=5.6 Hz, 1H), 6.83 (d, J=9.2 Hz, 2H), 6.90 (d, J=9.2 Hz, 2H), 6.91 (d, J=8.4 Hz, 1H), 7.07 (dd, J=8.4, 2.0 Hz, 1H), 7.24 (d, J=2.0 Hz, 1H), 7.46 (d, J=9.2 Hz, 2H), 7.51 (d, J=9.2 Hz, 1H), 8.50-8.90 (brs, 1H), 9.39 (s, 1H), 9.61 (s, 1H); MS (ES) m/z: 703.4 (MH+); HRMS Calcd. for C33H47N6O7S2 (MH+): 703.2948. Found: 703.2946.