1-Butanesulfonic acid → HCID 69655077、化合物

HRID 1061393ノート

反応式

HRID 1061393 の反応式
C(S(O)(=O)=O)CCC.O=[C:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][S:23]([CH2:26][CH2:27][CH2:28][CH3:29])(=[O:25])=[O:24])=[CH:18][CH:17]=2)[CH2:12][CH2:11]1.[NH2:30][CH2:31][C@H:32]([OH:47])[CH2:33][O:34][C:35]1[CH:44]=[CH:43][C:42]([OH:45])=[C:41]2[C:36]=1[CH2:37][CH2:38][C:39](=[O:46])[NH:40]2>>[OH:47][C@H:32]([CH2:33][O:34][C:35]1[CH:44]=[CH:43][C:42]([OH:45])=[C:41]2[C:36]=1[CH2:37][CH2:38][C:39](=[O:46])[NH:40]2)[CH2:31][NH:30][CH:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][S:23]([CH2:26][CH2:27][CH2:28][CH3:29])(=[O:25])=[O:24])=[CH:18][CH:17]=2)[CH2:12][CH2:11]1

参加物

4

反応物 3

HCID 499351-Butanesulfonic acidHCID 69655051HCID 69655051、化合物HCID 86584570N-[4-(4-Oxo-1-piperidinyl)phenyl]-1-butanesulfonamide

生成物 1

HCID 69655077HCID 69655077、化合物

実験手順

The title compound was prepared from butane-1-sulfonic acid ]4-(4-oxo-piperidine-1-yl)-phenyl]-amide (which was obtained in Example 228) and 5-(3-amino-(2S)-2-hydroxy-propoxy)-8-hydroxy-3,4-dihydro-1H-quinolin-2-one (which was obtained in Example 12) according to the procedure of Example 278 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.82 (t, J=7.3 Hz, 3H), 1.20-1.40 (m, 4H), 1.50-1.70 (m, 2H), 1.80-1.95 (m, 2H), 2.39 (t, J=7.3 Hz, 2H), 2.50-2.80 (m, 5H), 2.85 (t, J=7.3 Hz, 2H), 2.85-3.00 (m, 2H), 3.45-3.60 (m, 2H), 3.75-3.85 (m, 3H), 6.44 (d, J=8.7 Hz, 1H), 6.60 (d, J=8.7 Hz, 1H), 6.89 (d, J=9.0 Hz, 2H), 7.04 (d, J=9.0 Hz, 2H), 8.74 (s, 1H); MS (ES) m/z: 546.9 (MH+); HRMS Calcd. for C27H39N4O6S(MH+): 547.2590. Found: 547.2583.

出典と根拠

ORDレコード
ord-be1fd317e0344e5b8ce7a8b8e2f246e4
出典データセット
uspto-grants-2003_02
特許番号
US06525202B2

反応ノート

読み込み中…