反应详情

The title compound was prepared from 4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidine-1-yl)-phenyl]-benzensulfonamide (which was obtained in Example 225) and (1R)-2-amino-1-(3-chloro-phenyl)-ethanol (which was obtained in Example 1) according to the procedure of Example 278 as a brown solid; 1H NMR (300 MHz, DMSO-d6) δ 0.84 (t, J=6.9 Hz, 3H), 1.20-1.50 (m, 10H), 1.75-1.90 (m, 2H), 2.50-2.80 (m, 5H), 3.00-3.15 (m, 2H), 3.40-3.50 (m, 2H), 4.60 (dd, J=8.1, 3.8 Hz, 1H), 6.29 (t, J=5.7 Hz, 1H), 6.77 (d, J=9.1 Hz, 2H), 6.85 (d, J=9.1 Hz, 2H), 7.25-7.50 (m, 8H), 8.94 (s, 1H), 9.55 (brs, 1H); MS (ES) m/z: 628.1 (MH+); HRMS Calcd. for C32H43ClN5O4S(MH+): 628.2748. Found: 628.2718.