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HRID1061401

反应详情

EQUATION

反应方程式

HRID 1061401 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)COc1ccc(S(=O)(=O)Nc2ccc(N3CCC(=O)CC3)cc2)cc1
HCID69654907

未命名化合物

结构：CS(=O)(=O)Nc1cc([C@@H](O)CN=[N+]=[N-])ccc1Cl
HCID86584545

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)COc1ccc(S(=O)(=O)Nc2ccc(N3CCC(NC[C@H](O)c4ccc(Cl)c(NS(C)(=O)=O)c4)CC3)cc2)cc1
HCID90718134

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from {4-[4-(4-oxo-piperidine-1-yl)-phenylsulfamoyl]-phenoxy}-acetic acid methyl ester (which was obtained in Example 232) and N-[5-((1R)-2-azido-1-hydroxy-ethyl)-2-chloro-phenyl]-methanesulfonamide (which was obtained in Example 25) according to the procedure of Example 95 as a pale grey solid; 1H NMR (300 MHz, DMSO-d6) δ 1.20-1.40 (m, 2H), 1.75-1.90 (m, 2H), 2.50-2.80 (m, 5H), 2.97 (s, 3H), 3.40-3.55 (m, 2H), 3.69 (s, 3H), 4.63 (dd, J=8.0, 3.8 Hz, 1H), 4.87 (s, 2H), 6.77 (d, J=9.0 Hz, 2H), 6.87 (d, J=9.0Hz, 2H), 7.03 (d, J=9.0Hz, 2H), 7.17 (dd, J=8.3, 1.7 Hz, 1H), 7.43 (d, J=8.3 Hz, 1H), 7.43 (d, J=1.7 Hz, 1H), 7.62 (d, J=9.0 Hz, 2H); MS (ES) m/z: 667.0 (MH+); HRMS Calcd. for C29H36ClN4O8S2 (MH+): 667.1657. Found: 667.1651.