反应详情

7.6 ml ethanol, 2.5 ml of THF and 1.3 ml of 1N hydrochloric acid were added to 312.5 mg of ethyl 1-cyclopropyl-9-methyl-8-(1-methylisoindoline-5-yl)-4-oxo-4H-quinolizine-3-carboxylate (XIV) and the resulting mixture was stirred at room temperature for 30 minutes. The solvent was distilled off under reduced pressure and water was added to the resulting residue and the resulting residue was washed with ethyl acetate, and thereafter, the resulting water layer was concentrated under reduced pressure. 10 ml of water, 5 ml of ethanol and 3 ml of 1N sodium hydroxide were added to the residue, which was stirred at 50° C. for 3 hours. The reaction solution was concentrated under reduced pressure, and thereafter, dissolved in 4 ml of water and neutralized with 1N hydrochloric acid. The precipitated crystal was separated by filtering to obtain 139.1 mg of 1-cyclopropyl-9-methyl-8-(1-methylisoindoline-5-yl)-4-oxo-4H-quinolizine-3-carboxylic acid.

1. distillationThe solvent was distilled off under reduced pressure and water
2. additionwas added to the resulting residue
3. washthe resulting residue was washed with ethyl acetate
4. concentrationthe resulting water layer was concentrated under reduced pressure
5. addition10 ml of water, 5 ml of ethanol and 3 ml of 1N sodium hydroxide were added to the residue, which
6. stirringwas stirred at 50° C. for 3 hours
7. concentrationThe reaction solution was concentrated under reduced pressure
8. dissolutiondissolved in 4 ml of water and neutralized with 1N hydrochloric acid
9. customThe precipitated crystal was separated
10. filtrationby filtering