反应详情

This was prepared in 62% yield from 5-chloro-2-(2-fluorophenyl)-[1,8]naphthyridine (from step a) and 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile (from Example 2, step e) using a similar procedure to that described in step a. δH (400 MHz, CDCl3) 7.20 (1H, ddd, J 11.7, 8.2 and 1.2), 7.34 (1H, td, J 7.4, 1.2), 7.42-7.48 (2H, m), 7.50 (1H, d, J 4.3), 7.54 (1H, td, J 7.4, 1.2), 7.60-7.65 (3H, m), 7.71 (1H, td, J 7.4, 1.2), 7.84 (1H, dd, J 7.8, 0.8), 8.09 (1H, dd, J 8.6 and 2.3), 8.42 (1H, td, J 7.8, 2.0), 8.49 (1H, d, J 8.6), 9.18 (1H, d, J 4.7). m/z (ES+) 420 [MH]+.