反应详情

5 mmol of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanal (prepared according to standard methods (Swern oxidation) with 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanol and oxalyl chloride in DMSO at −45° C.) and 5 mmol of 3-phenylpropyltriphenylphosphonium bromide (prepared from triphenylphosphine and 3-phenylpropyl bromide in toluene under reflux for 12 h) are treated as described in Example 51. The 1-(1H-imidazol-4-yl)-6-phenyl-3-hexene is hydrogenated as described in Example 52. The title compound is crystallized in the form of hydrogen oxalate in ethanol and diethyl ether.

1. customThe title compound is crystallized in the form of hydrogen oxalate in ethanol and diethyl ether