HRID10706

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74065

Benzenesulfonamide, p-acetyl- (6CI,7CI,8CI)

C8H9NO3S

结构：COc1cc(OC)c(-c2cc3ccccc3n2C(=O)OC(C)(C)C)cc1C=O

HCID16116307

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OC)c(-c2cc3ccccc3n2C(=O)OC(C)(C)C)cc1/C=C/C(=O)c1ccc(S(N)(=O)=O)cc1

HCID10415444

未命名化合物

收率 40%

PROCEDURE

实验过程

The title compound was prepared by condensing 4-acetyl-benzenesulfonamide (Ex-26A) and 2-(5-formyl-2,4-dimethoxy-phenyl)-indole-1-carboxylic acid tert-butyl ester (Ex-36A) in a similar manner as described in Ex-22. Yellow solid, 40% yield, mp 120–122° C. 1H-NMR (CDCl3) δ 8.01–8.19 (m, 6H), 7.68 (s, 1H), 7.56 (d, J=8 Hz, 1H), 7.46 (d, J=16 Hz, 1H), 7.21–7.35 (m, 2H), 6.53 (d, J=14 Hz, 2H), 5.01 (s, 2H), 4.00 (s, 3H), 3.85 (s, 3H), 1.42 (s, 9H), MS m/z=563 ([M+H]+). HRMS (ES+) Calcd. for C30H30N2O7S: 563.1852. Found: 563.1862.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5d7a874c547f4e10bf5fff9813a4f7a7
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07094801B2
来源说明: uspto-grants-2006_08

反应 SMILES

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[C:14]([O:18][C:19]([N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]1[C:30]1[CH:35]=[C:34]([CH:36]=O)[C:33]([O:38][CH3:39])=[CH:32][C:31]=1[O:40][CH3:41])=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]1[C:30]1[CH:35]=[C:34](/[CH:36]=[CH:2]/[C:1](=[O:3])[C:4]2[CH:5]=[CH:6][C:7]([S:10]([NH2:13])(=[O:11])=[O:12])=[CH:8][CH:9]=2)[C:33]([O:38][CH3:39])=[CH:32][C:31]=1[O:40][CH3:41])=[O:20])([CH3:17])([CH3:16])[CH3:15]