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HRID1072354

反应详情

EQUATION

反应方程式

HRID 1072354 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)CI
HCID3727

Iodoacetamide

C2H4INO

结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)c5cccnc5)c4s3)[C@H](C)[C@H]12
HCID68934911

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)c5ccc[n+](CC(N)=O)c5)c4s3)[C@H](C)[C@H]12.[I-]
HCID131725006

未命名化合物

收率 112.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate (105.5 mg) was suspended in 2 ml of acetonitrile to prepare a suspension. 2-Iodoacetamide (340 mg) was added to the suspension, and the mixture was stirred at 50° C. for 6 hr. The reaction solution was concentrated under the reduced pressure, 5 ml of ethyl acetate was added to the concentrate, and the insolubles were collected by filtration to give 157 mg of 4-nitrobenzyl (1S,5R,6S)-2-[7-(1-carbamoylmethylpyridinium-3-yl)carbonylimidazo-[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate iodide.

WORKUP

后处理

  1. customto prepare a suspension
  2. concentrationThe reaction solution was concentrated under the reduced pressure, 5 ml of ethyl acetate
  3. additionwas added to the concentrate
  4. filtrationthe insolubles were collected by filtration