反应详情

Next, 2.02 g (11.4 mmol) of the above (+)-2-methyl octanoyl chloride and 3 ml of nitrobenzene were cooled to 0° C. in a flask and added with 3.06 g (22.9 mmol) of anhydrous aluminum chloride with stirring, which were stirred at room temperature for 30 minutes. Thereafter, 2.89 g (7 mmol) of (+)-biphenyl-2-methyloctanoate biphenyl dissolved in 3 ml of nitrobenzene was added thereto, which was reacted by stirring at room temperature for 140 hours. After the completion of the reaction, 2 normal hydrochloric acid and ice were added and extracted with chloroform. The extract was washed with water, dried on anhydrous magnesium sulfate and distilled to remove the solvent. The residue was purified through a column chromatography of silica gel to obtain 1.55 g (yield: 49%) of an oily (+)-4-(2-methyloctanoyl) biphenyl-2-methyloctanoate.

1. stirringwhich were stirred at room temperature for 30 minutes
2. additionwas added
3. customwhich was reacted
4. stirringby stirring at room temperature for 140 hours
5. additionwere added
6. extractionextracted with chloroform
7. washThe extract was washed with water
8. dry with materialdried on anhydrous magnesium sulfate
9. distillationdistilled
10. customto remove the solvent
11. customThe residue was purified through a column chromatography of silica gel