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HRID1073831

反应详情

EQUATION

反应方程式

HRID 1073831 的结构方程式

REACTANTS

反应物

3
结构：C=O
HCID712

Formaldehyde

CH2O

结构：C1CCNCC1
HCID8082

Piperidine

C5H11N

结构：CCOC(=O)C1=C(C)NC(CS)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1
HCID11675833

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(C)NC(CSCN2CCCCC2)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1
HCID22156956

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-2-mercaptomethyl-1,4-dihydropyridine (mg 300), formaldehyde (37%); μl 90) and piperidine (μ87) in ethanol (ml 3) is stirred at 40° C. under nitrogen atmosphere, for 24 hrs. After evaporation at reduced pressure the residue is purified by chromatography (SiO2 9 g eluent diisopropyl ether/ hexane 60/40) to give 2-(N-piperidinylmethylthiomethyl)-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine as a yellow oil.

WORKUP

后处理

  1. customAfter evaporation at reduced pressure the residue
  2. customis purified by chromatography (SiO2 9 g eluent diisopropyl ether/ hexane 60/40)