反应详情

温度

0 °C

To a 0° C. solution of the title compound of Example 31, 5-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-methoxy-2-cyclohexen-1-one (500 mg, 1.15 mmole), in ether (20 ml) was added lithium aluminum hydride (20 mg, 0.53 mmole). The reaction mixture was stirred for 30 minutes at 0° C., acidified with 1 N hydrochloric acid and stirred for 2 hours at room temperature. The ether phase was removed, washed successively with saturated sodium bicarbonate, saturated sodium chloride, dried over magnesium sulfate and evaporated. The crude oil was purified via column chromatography on 100 g of silica gel eluted with 50% ether-pentane to yield 353 mg (76%) of the title compound as an oil.

1. stirringstirred for 2 hours at room temperature
2. customThe ether phase was removed
3. washwashed successively with saturated sodium bicarbonate, saturated sodium chloride
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customThe crude oil was purified via column chromatography on 100 g of silica gel
7. washeluted with 50% ether-pentane