反应详情

温度

70 °C

0.2 ml of trifluoroacetic acid was added to a solution of 4 g of the Compound 1 obtained in Example 1 in water-methanol. The mixture was stirred for 48 hours at 70° C. After the reaction was completed, methanol was evaporated and the crystals were collected by filtration and dried to give 2.3 g of 6-hydroxy-2-(4-hydroxybenzoyl)benzothiazole (Compound 7). mp: 46° C. 1H-NMR(aceton-d6): 7.01(d,J=8.9 Hz,2H), 7.18(dd,J=8.9,2.4 Hz,1H), 7.52(d,J=2.4 Hz,1H), 8.05(d,J=8.9 Hz,1H), 8.58(d,J=8.9 Hz,2H), 9.15(br,1H), 9.40(br,1H) IR(KBr) cm-1 : 3463, 1602, 1589, 1491, 1249, 1176, 1119, 875 MS m/z: 271(M+), 243, 121 Elementary analysis (C14H9NO3S 0.8 H2O): Calculated (C=58.84,H=3.74,N=4.90); Found (C=58.78,H=3.55,N=4.54)

1. custommethanol was evaporated
2. filtrationthe crystals were collected by filtration
3. customdried