反应详情

温度

75 °C

A mixture of 0.200 gm (0.74 mMol) 5-(N-[acetyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.125 gm (3.31 mMol) lithium aluminum hydride in 40 mL tetrahydrofuran was heated at 75° C. for 18 hours. The reaction mixture was cooled to 0° C. and was then treated with sodium sulfate decahydrate. After vigorous stirring the reaction mixture was filtered through a pad of celite and the filtrate concentrated under reduced pressure. The residue was subjected to flash silica gel chromatography, eluting with dichloromethane containing from 0-20% methanol. Fractions containing product were combined and concentrated under reduced pressure to provide 0.10 gm (54%) of the title compound.

1. temperatureThe reaction mixture was cooled to 0° C.
2. filtrationwas filtered through a pad of celite
3. concentrationthe filtrate concentrated under reduced pressure
4. washeluting with dichloromethane containing from 0-20% methanol
5. additionFractions containing product
6. concentrationconcentrated under reduced pressure