反应详情

After adding 2.6 ml (17.23 mmoles) of 1,4-dioxa-8-azaspiro[4,5]decane to the solution of 2.0 g (6.89 mmoles) of 2-(4,4-ethylenedioxy-1-piperidinyl)-4,6-dichloropyrimidine in 40 ml of n-butanol, the reaction mixture is boiled under reflux for 4 hours, then evaporated. The evaporation residue is distributed between 50 ml of chloroform and 5 ml of 10% sodium hydroxide solution. After separation the organic phase is washed 4 times with 10 ml of water each, then dried and evaporated. After recrystallizing the obtained product from hexane the title compound is obtained in a yield of 2.51 g (91%), m.p.: 130°-131° C.

1. temperatureunder reflux for 4 hours
2. customevaporated
3. customAfter separation the organic phase
4. washis washed 4 times with 10 ml of water each,
5. customthen dried
6. customevaporated
7. customAfter recrystallizing the obtained product from hexane the title compound
8. customis obtained in a yield of 2.51 g (91%), m.p.: 130°-131° C.